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Article

Efficient identification of human immunodeficiency virus type 1 mutants resistant to a protease inhibitor by using a random mutant library.

Antimicrobial agents and chemotherapy - 1 Nov 2011

Kim Sanggu, Kim Yun-Cheol, Qi Hangfei, Su Kunkai, Morrison Sherie L, Chow Samson A

Abstract excerpt

Emergence of drug-resistant mutant viruses during the course of antiretroviral therapy is a major hurdle that limits the success of chemotherapeutic treatment to suppress human immunodeficiency virus type 1 (HIV-1) replication and AIDS progression. Development of new drugs and careful patient management based on resistance genotyping data are important for enhancing therapeutic efficacy. However, identifying...

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Identifiers

PMID: 21876045
DOI: 10.1128/AAC.00687-11
PMCID: PMC3195011

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