Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proviral HIV-genome-wide and pol-gene specific Zinc Finger Nucleases: Usability for targeted HIV gene therapy

22 Jul 2011

Abstract excerpt

BACKGROUND: Infection with HIV, which culminates in the establishment of a latent proviral reservoir, presents formidable challenges for ultimate cure. Building on the hypothesis that ex-vivo or even in-vivo abolition or disruption of HIV-gene/genome-action by target mutagenesis or excision can irreversibly abrogate HIV's innate fitness to replicate and survive, we previously identified the isoschizomeric...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to HIV/AIDS drug development and treatment
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21781315
DOI: 10.1186/1742-4682-8-26

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proviral HIV-genome-wide and pol-gene specific Zinc Finger Nucleases: Usability for targeted HIV gene therapyPMID 21781315Read ↗

Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cellsSemantic proximity Read ↗

Identity of zinc finger nucleases with specificity to herpes simplex virus type II genomic DNA: novel HSV-2 vaccine/therapy precursors.Semantic proximity Read ↗

The therapeutic landscape of HIV-1 via genome editingSemantic proximity Read ↗

Generation of an HIV Resistant T-cell Line by Targeted “Stacking” of Restriction FactorsSemantic proximity Read ↗

The clinical applications of genome editing in HIVSemantic proximity Read ↗

Broadly active zinc finger protein-guided transcriptional activation of HIVSemantic proximity Read ↗

Detection of treatment-resistant infectious HIV after genome-directed antiviral endonuclease therapy.Semantic proximity Read ↗

Targeted DNA Mutagenesis for the Cure of Chronic Viral InfectionsSemantic proximity Read ↗

Zinc-Finger Nucleases Induced by HIV-1 Tat Excise HIV-1 from the Host Genome in Infected and Latently Infected CellsSemantic proximity Read ↗

Targeted genome editing in human cells with zinc finger nucleases constructed via modular assembly.Semantic proximity Read ↗

Nucleocapsid mutations turn HIV-1 into a DNA-containing virus.Semantic proximity Read ↗

Strict Conservation of the Retroviral Nucleocapsid Protein Zinc Finger Is Strongly Influenced by Its Role in Viral Infection Processes: Characterization of HIV-1 Particles Containing Mutant Nucleocapsid Zinc-Coordinating SequencesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.