Article
Generation of mice with a conditional allele of the p120 Ras GTPase-activating protein.
Genesis (New York, N.Y. : 2000) - 1 Dec 2007
Lapinski Philip E, Bauler Timothy J, Brown Eric J, Hughes Elizabeth D, Saunders Thomas L, King Philip D
Abstract excerpt
p120 Ras GTPase-activating protein (RasGAP) encoded by the rasa1 gene in mice is a prototypical member of the RasGAP family of proteins involved in negative-regulation of the p21 Ras proto-oncogene. RasGAP has been implicated in signal transduction through a number of cell surface receptors. In humans, inactivating mutations in the coding region of the RASA1 gene cause capillary malformation arteriovenous...
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