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Article

Sulfur-Oxygen Chalcogen Bonding Mediates AdoMet Recognition in the Lysine Methyltransferase SET7/9.

ACS chemical biology - 18 Mar 2016

Fick Robert J, Kroner Grace M, Nepal Binod, Magnani Roberta, Horowitz Scott, Houtz Robert L, Scheiner Steve, Trievel Raymond C

Abstract excerpt

Recent studies have demonstrated that carbon-oxygen (CH···O) hydrogen bonds have important roles in S-adenosylmethionine (AdoMet) recognition and catalysis in methyltransferases. Here, we investigate noncovalent interactions that occur between the AdoMet sulfur cation and oxygen atoms in methyltransferase active sites. These interactions represent sulfur-oxygen (S···O) chalcogen bonds in which the oxygen atom...

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PMID: 26713889
DOI: 10.1021/acschembio.5b00852

Genes

SET

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