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Article

Genetic variants in cell cycle control pathway confer susceptibility to aggressive prostate carcinoma.

The Prostate - 1 Apr 2016

Kibel Adam S, Ahn Jiyoung, Isikbay Masis, Klim Aleksandra, Wu William S, Hayes Richard B, Isaacs William B, Daw E Warwick

Abstract excerpt

BACKGROUND: Because a significant number of patients with prostate cancer (PCa) are diagnosed with disease unlikely to cause harm, genetic markers associated with clinically aggressive PCa have potential clinical utility. Since cell cycle checkpoint dysregulation is crucial for the development and progression of cancer, we tested the hypothesis that common germ-line variants within cell cycle genes were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26708993
DOI: 10.1002/pros.23139

Genes

CCNG1
MDM2
CCNC
CDK2
CDK5
CCND3
CCNT2
CDK6
SKP2
SMAD3
WEE1
YWHAB
YWHAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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