Article
Increased Nigral SLC6A3 Activity in Schizophrenia Patients: Findings From the Toronto-McLean Cohorts.
Schizophrenia bulletin - 1 May 2016
Kennedy James L, Xiong Nian, Yu Jinlong, Zai Clement C, Pouget Jennie G, Li Jie, Liu Kefu, Qing Hong, Wang Tao, Martin Eden, Levy Deborah L, Lin Zhicheng
Abstract excerpt
SLC6A3, which encodes the primary regulator of extracellular dopamine (DA) concentration, the DA transporter, has been implicated in schizophrenia (SCZ). However, the details of its genetic effect on risk remain largely unknown. The purpose of this candidate gene study was to identify a specificSLC6A3activity associated with SCZ by using functional genetic approaches. We first examined gene activity in DA neurons...
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