Article
The dopamine transporter gene SLC6A3: multidisease risks.
Molecular psychiatry - 1 Feb 2022
Reith Maarten E A, Kortagere Sandhya, Wiers Corinde E, Sun Hui, Kurian Manju A, Galli Aurelio, Volkow Nora D, Lin Zhicheng
Abstract excerpt
The human dopamine transporter gene SLC6A3 has been consistently implicated in several neuropsychiatric diseases but the disease mechanism remains elusive. In this risk synthesis, we have concluded that SLC6A3 represents an increasingly recognized risk with a growing number of familial mutants associated with neuropsychiatric and neurological disorders. At least five loci were related to common and severe...
Topics
- Attention Deficit Disorder with Hyperactivity
- Dopamine Plasma Membrane Transport Proteins
- Haplotypes
- Humans
- Mutation
- Phenotype