Article
A network of dopaminergic gene variations implicated as risk factors for schizophrenia.
Human molecular genetics - 1 Mar 2008
Talkowski Michael E, Kirov George, Bamne Mikhil, Georgieva Lyudmila, Torres Gonzalo, Mansour Hader, Chowdari Kodavali V, Milanova Vihra, Wood Joel, McClain Lora, Prasad Konasale, Shirts Brian, Zhang Jianping, O'Donovan Michael C, Owen Michael J, Devlin Bernie, Nimgaonkar Vishwajit L
Abstract excerpt
We evaluated the hypothesis that dopaminergic polymorphisms are risk factors for schizophrenia (SZ). In stage I, we screened 18 dopamine-related genes in two independent US Caucasian samples: 150 trios and 328 cases/501 controls. The most promising associations were detected with SLC6A3 (alias DAT), DRD3, COMT and SLC18A2 (alias VMAT2). In stage II, we comprehensively evaluated these four genes by genotyping 68...
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