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Article

Postmortem investigations of the pathophysiology of schizophrenia: the role of susceptibility genes.

Journal of psychiatry & neuroscience : JPN - 1 Jul 2004

Perlman William R, Weickert Cynthia Shannon, Akil Mayada, Kleinman Joel E

Abstract excerpt

Despite robust evidence for the heritability of schizophrenia, postmortem studies have not traditionally linked cellular and molecular neuropathology with underlying genetic mechanisms in this disorder. The completion of the first draft of the Human Genome Project and the use of novel strategies in studying complex genetic disorders including schizophrenia have led to the identification of a growing list of...

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PMID: 15309045
PMCID: PMC446223

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