Article
Association of serotonin transporter gene (SLC6A4) polymorphisms with schizophrenia susceptibility and symptoms in a Chinese-Han population.
Progress in neuro-psychopharmacology & biological psychiatry - 1 Jul 2013
Li Wenqiang, Yang Yongfeng, Lin Juntang, Wang Shuai, Zhao Jingyuan, Yang Ge, Wang Xiujuan, Ding Minli, Zhang Hongxing, Lv Luxian
Abstract excerpt
Schizophrenia (SZ) is a complex psychiatric disorder with a strong genetic component. The serotonin transporter (SERT), encoded by solute carrier family 6 member 4 (SLC6A4), regulates synaptic concentrations of serotonin and thereby strongly influences perception, mood, emotion, behavior, and cognition, all of which are severely disturbed in SZ. Two variable numbers of tandem repeat (VNTR) polymorphisms and...
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