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Carbazole Derivatives as Kinase-Targeting Inhibitors for Cancer Treatment

17 Jan 2020

Abstract excerpt

Protein Kinases (PKs) are a heterogeneous family of enzymes that modulate several biological pathways, including cell division, cytoskeletal rearrangement, differentiation and apoptosis. In particular, due to their crucial role during human tumorigenesis and cancer progression, PKs are ideal targets for the design and development of effective and low toxic chemotherapeutics and represent the second group of drug...

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PMID: 31951166
DOI: 10.2174/1389557520666200117144701

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