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Article

Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei

9 Jul 2013

Abstract excerpt

Protein kinases are potentially attractive therapeutic targets for neglected parasitic diseases, including African trypanosomiasis caused by the protozoan, Trypanosoma brucei. How to prioritize T. brucei kinases and quantify their intracellular engagement by small-molecule inhibitors remain unsolved problems. Here, we combine chemoproteomics and RNA interference to interrogate trypanosome kinases bearing a...

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PMID: 23853713
DOI: 10.7554/elife.00712

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