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Article

Increased Aortic Valve Calcification in Familial Hypercholesterolemia: Prevalence, Extent, and Associated Risk Factors.

Journal of the American College of Cardiology - 22 Dec 2015

Ten Kate Gert-Jan R, Bos Sven, Dedic Admir, Neefjes Lisan A, Kurata Akira, Langendonk Janneke G, Liem Anho, Moelker Adriaan, Krestin Gabriel P, de Feyter Pim J, Roeters van Lennep Jeanine E, Nieman Koen, Sijbrands Eric J

Abstract excerpt

BACKGROUND: Familial hypercholesterolemia is typically caused by LDL receptor (LDLR) mutations that result in elevated levels of LDL cholesterol (LDL-C). In homozygous FH, the prevalence of aortic valve calcification (AoVC) reaches 100% and is often symptomatic. OBJECTIVES: The objective of this study was to investigate the prevalence, extent, and risk-modifiers of AoVC in heterozygous FH (he-FH) that are...

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Identifiers

PMID: 26700830
DOI: 10.1016/j.jacc.2015.09.087

Genes

LDLR

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