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Article

Oocyte activation, phospholipase C zeta and human infertility.

Human reproduction update - 1 Jan 2000

Kashir J, Heindryckx B, Jones C, De Sutter P, Parrington J, Coward K

Abstract excerpt

BACKGROUND: Mammalian oocytes are activated by intracellular calcium (Ca(2+)) oscillations following gamete fusion. Recent evidence implicates a sperm-specific phospholipase C zeta, PLCζ, which is introduced into the oocyte following membrane fusion, as the responsible factor. This review summarizes the current understanding of human oocyte activation failure and describes recent discoveries linking certain cases...

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Share to Calcium Signaling
Share to Infertility, Male
Share to Models, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oocytes

Share to Phosphoinositide Phospholipase C

Share to Sperm Injections, Intracytoplasmic

Share to Sperm-Ovum Interactions

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Source

Identifiers

PMID: 20573804
DOI: 10.1093/humupd/dmq018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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