Article
Limitations of GCTA as a solution to the missing heritability problem.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jan 2016
Krishna Kumar Siddharth, Feldman Marcus W, Rehkopf David H, Tuljapurkar Shripad
Abstract excerpt
Genome-wide association studies (GWASs) seek to understand the relationship between complex phenotype(s) (e.g., height) and up to millions of single-nucleotide polymorphisms (SNPs). Early analyses of GWASs are commonly believed to have "missed" much of the additive genetic variance estimated from correlations between relatives. A more recent method, genome-wide complex trait analysis (GCTA), obtains much higher...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.