Article
Methodological Considerations in Estimation of Phenotype Heritability Using Genome-Wide SNP Data, Illustrated by an Analysis of the Heritability of Height in a Large Sample of African Ancestry Adults.
PloS one - 1 Jan 2015
Chen Fang, He Jing, Zhang Jianqi, Chen Gary K, Thomas Venetta, Ambrosone Christine B, Bandera Elisa V, Berndt Sonja I, Bernstein Leslie, Blot William J, Cai Qiuyin, Carpten John, Casey Graham, Chanock Stephen J, Cheng Iona, Chu Lisa, Deming Sandra L, Driver W Ryan, Goodman Phyllis, Hayes Richard B, Hennis Anselm J M, Hsing Ann W, Hu Jennifer J, Ingles Sue A, John Esther M, Kittles Rick A, Kolb Suzanne, Leske M Cristina, Millikan Robert C, Monroe Kristine R, Murphy Adam, Nemesure Barbara, Neslund-Dudas Christine, Nyante Sarah, Ostrander Elaine A, Press Michael F, Rodriguez-Gil Jorge L, Rybicki Ben A, Schumacher Fredrick, Stanford Janet L, Signorello Lisa B, Strom Sara S, Stevens Victoria, Van Den Berg David, Wang Zhaoming, Witte John S, Wu Suh-Yuh, Yamamura Yuko, Zheng Wei, Ziegler Regina G, Stram Alexander H, Kolonel Laurence N, Le Marchand Loïc, Henderson Brian E, Haiman Christopher A, Stram Daniel O
Abstract excerpt
Height has an extremely polygenic pattern of inheritance. Genome-wide association studies (GWAS) have revealed hundreds of common variants that are associated with human height at genome-wide levels of significance. However, only a small fraction of phenotypic variation can be explained by the aggregate of these common variants. In a large study of African-American men and women (n = 14,419), we genotyped and...
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