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Article

Effects of mutations of ABCA1 in the first extracellular domain on subcellular trafficking and ATP binding/hydrolysis.

The Journal of biological chemistry - 7 Mar 2003

Tanaka Arowu R, Abe-Dohmae Sumiko, Ohnishi Tomohiro, Aoki Ryo, Morinaga Gaku, Okuhira Kei-ichiro, Ikeda Yuika, Kano Fumi, Matsuo Michinori, Kioka Noriyuki, Amachi Teruo, Murata Masayuki, Yokoyama Shinji, Ueda Kazumitsu

Abstract excerpt

ABCA1 mediates release of cellular cholesterol and phospholipid to form high density lipoprotein (HDL). The three different mutants in the first extracellular domain of human ABCA1 associated with Tangier disease, R587W, W590S, and Q597R, were examined for their subcellular localization and function by using ABCA1-GFP fusion protein stably expressed in HEK293 cells. ABCA1-GFP expressed in HEK293 was fully...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12509412
DOI: 10.1074/jbc.M206885200

Genes

ABCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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