Article
Mutations in V-ATPase in follicular lymphoma activate autophagic flux creating a targetable dependency.
Autophagy - 1 Feb 2023
Wang Fangyang, Yang Ying, Klionsky Daniel J, Malek Sami N
Abstract excerpt
The recent discovery of recurrent gene mutations in chaperones or components of the vacuolar-type H+-translocating ATPase (V-ATPase) in follicular lymphoma (FL) was an unexpected finding. The application of whole exome sequencing and targeted gene re-sequencing has resulted in the identification of mutations in ATP6AP1, ATP6V1B2 and VMA21 in a combined 30% of FL, together constituting a major novel mutated...
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