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Article

CREBBP histone acetyltransferase domain mutations predict response to mTOR inhibition in relapsed/refractory follicular lymphoma.

British journal of haematology - 1 Nov 2024

Kumar Emil Arjun, Korfi Koorosh, Bewicke-Copley Findlay, Close Karina, Heward James, Witzig Thomas, Leukam Michael, Ansell Stephen, Scott Jessica, Clear Andrew, Efeyan Alejo, Green Michael, Siebert Reiner, Peck Barrie, Calaminici Maria, Wang Jun, Smith Sonali, Novak Anne, Fitzgibbon Jude, Okosun Jessica

Abstract excerpt

Despite the clinical and molecular heterogeneity of follicular lymphoma (FL), there remains a lack of biomarker-directed therapeutic approaches in routine clinical practice, with the notable exception of the EZH2 inhibitor tazemetostat in EZH2-mutant FL. Here we examined whether gene mutation status predicts response to clinical mTOR inhibitors (mTORi) in FL, by performing targeted mutational profiling of...

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CREB-Binding Protein
Everolimus
Lymphoma, Follicular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Domains

TOR Serine-Threonine Kinases

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Identifiers

PMID: 39188028
DOI: 10.1111/bjh.19671

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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