Article
Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma.
Science translational medicine - 28 Jun 2017
Oricchio Elisa, Katanayeva Natalya, Donaldson Maria Christine, Sungalee Stephanie, Pasion Joyce P, Béguelin Wendy, Battistello Elena, Sanghvi Viraj R, Jiang Man, Jiang Yanwen, Teater Matt, Parmigiani Anita, Budanov Andrei V, Chan Fong Chun, Shah Sohrab P, Kridel Robert, Melnick Ari M, Ciriello Giovanni, Wendel Hans-Guido
Abstract excerpt
Follicular lymphoma (FL) is an incurable form of B cell lymphoma. Genomic studies have cataloged common genetic lesions in FL such as translocation t(14;18), frequent losses of chromosome 6q, and mutations in epigenetic regulators such as EZH2 Using a focused genetic screen, we identified SESTRIN1 as a relevant target of the 6q deletion and demonstrate tumor suppression by SESTRIN1 in vivo. Moreover, SESTRIN1 is...
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