Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High heritability of antimycobacterial immunity in an area of hyperendemicity for tuberculosis disease.

The Journal of infectious diseases - 1 Jan 2010

Cobat Aurelie, Gallant Caroline J, Simkin Leah, Black Gillian F, Stanley Kim, Hughes Jane, Doherty T Mark, Hanekom Willem A, Eley Brian, Beyers Nulda, Jaïs Jean-Philippe, van Helden Paul, Abel Laurent, Hoal Eileen G, Alcaïs Alexandre, Schurr Erwin

Abstract excerpt

Human antimycobacterial immunity is a critical component of tuberculosis (TB) pathogenesis that is often used to infer the presence of TB infection. We report high heritability (>50%) for in vitro secretion of tumor necrosis factor alpha and interferon gamma (IFN-gamma), and the frequency of anti...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endemic Diseases

Share to Immunity, Innate

Share to Interferon-gamma

Share to Principal Component Analysis

Share to South Africa

Share to Tuberculosis

Source

Identifiers

PMID: 19938975
DOI: 10.1086/648611

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19938975-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High heritability of antimycobacterial immunity in an area of hyperendemicity for tuberculosis disease.PMID 19938975Read ↗

Heritability analysis of cytokines as intermediate phenotypes of tuberculosis.Semantic proximity Read ↗

The immunogenetics of tuberculosis (TB) susceptibility.Semantic proximity Read ↗

Host genomics and control of tuberculosis infection.Semantic proximity Read ↗

Mendelian susceptibility to mycobacterial disease: IFN-γ-driven immunity collapse underlies heterogeneous infections.Semantic proximity Read ↗

The Role of Host Genetics (and Genomics) in Tuberculosis.Semantic proximity Read ↗

Human genetics of tuberculosis: a long and winding road.Semantic proximity Read ↗

The monogenic basis of human tuberculosis.Semantic proximity Read ↗

Molecular immunity to mycobacteria: knowledge from the mutation and phenotype spectrum analysis of Mendelian susceptibility to mycobacterial diseases.Semantic proximity Read ↗

Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses.Semantic proximity Read ↗

Major Loci on Chromosomes 8q and 3q Control Interferon γ Production Triggered by Bacillus Calmette-Guerin and 6-kDa Early Secretory Antigen Target, Respectively, in Various Populations.Semantic proximity Read ↗

Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi.Semantic proximity Read ↗

Concise whole blood transcriptional signatures for incipient tuberculosis: A systematic review and patient-level pooled meta-analysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.