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Article

Attenuated RND1 Expression Confers Malignant Phenotype and Predicts Poor Prognosis in Hepatocellular Carcinoma.

Annals of surgical oncology - 1 Mar 2017

Komatsu Hisateru, Iguchi Tomohiro, Masuda Takaaki, Hirata Hidenari, Ueda Masami, Kidogami Shinya, Ogawa Yushi, Sato Kuniaki, Hu Qingjiang, Nambara Sho, Saito Tomoko, Sakimura Shotaro, Uchi Ryutaro, Ito Shuhei, Eguchi Hidetoshi, Sugimachi Keishi, Eguchi Hidetoshi, Doki Yuichiro, Mori Masaki, Mimori Koshi

Abstract excerpt

BACKGROUND: The RND1 gene encodes a protein that belongs to the Rho GTPase family, which regulates various cellular functions. Depletion of RND1 expression activates the oncogenic Ras signaling pathway. In this study, we aimed to clarify the clinical significance of RND1 expression in predicting prognosis and to investigate its biological role in human hepatocellular carcinoma (HCC). METHODS: The association...

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Identifiers

PMID: 27770342
DOI: 10.1245/s10434-016-5573-9

Genes

RND1

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