Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene.

Oncogene - 19 Nov 2009

Chua Y L, Ito Y, Pole J C M, Newman S, Chin S-F, Stein R C, Ellis I O, Caldas C, O'Hare M J, Murrell A, Edwards P A W

Abstract excerpt

Neuregulin-1 (NRG1) is both a candidate oncogene and a candidate tumour suppressor gene. It not only encodes the heregulins and other mitogenic ligands for the ERBB family, but also causes apoptosis in NRG1-expressing cells. We found that most breast cancer cell lines had reduced or undetectable...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Aberrations
Share to Chromosomes, Human, Pair 8
Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Gene Silencing

Share to Genes, Tumor Suppressor

Share to Neuregulin-1

Share to Transcription Initiation Site

Source

Open in PubMed Open full text

Identifiers

PMID: 19802002
DOI: 10.1038/onc.2009.259
PMCID: PMC2789334

Genes

NRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19802002-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene.PMID 19802002Read ↗

NRG1 gene rearrangements in clinical breast cancer: identification of an adjacent novel amplicon associated with poor prognosisSemantic proximity Read ↗

Newly Identified Cancer-Associated Role of Human Neuronal Growth Regulator 1 (NEGR1)Semantic proximity Read ↗

NR4A1-mediated apoptosis suppresses lymphomagenesis and is associated with a favorable cancer-specific survival in patients with aggressive B-cell lymphomasSemantic proximity Read ↗

Development of an Autocrine Neuregulin Signaling Loop with Malignant Transformation of Human Breast Epithelial CellsSemantic proximity Read ↗

Expression profile of the N-myc Downstream Regulated Gene 2 (NDRG2) in human cancers with focus on breast cancerSemantic proximity Read ↗

RERG Is a Novel ras-related, Estrogen-regulated and Growth-inhibitory Gene in Breast CancerSemantic proximity Read ↗

The role of the neuregulins in the nucleusSemantic proximity Read ↗

A Role for Neuregulin-1 in Promoting Keloid Fibroblast Migration via ErbB2-mediated SignalingSemantic proximity Read ↗

NDN is an imprinted tumor suppressor gene that is downregulated in ovarian cancers through genetic and epigenetic mechanisms.Semantic proximity Read ↗

Aberrant Expression of Novel and Previously Described Cell Membrane Markers in Human Breast Cancer Cell Lines and TumorsSemantic proximity Read ↗

RRIG1 Mediates Effects of Retinoic Acid Receptor β2 on Tumor Cell Growth and Gene Expression through Binding to and Inhibition of RhoASemantic proximity Read ↗

Aberrations of <i>NEGR1</i> on 1p31 and <i>MYEOV</i> on 11q13 in neuroblastomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.