Article
The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene.
Oncogene - 19 Nov 2009
Chua Y L, Ito Y, Pole J C M, Newman S, Chin S-F, Stein R C, Ellis I O, Caldas C, O'Hare M J, Murrell A, Edwards P A W
Abstract excerpt
Neuregulin-1 (NRG1) is both a candidate oncogene and a candidate tumour suppressor gene. It not only encodes the heregulins and other mitogenic ligands for the ERBB family, but also causes apoptosis in NRG1-expressing cells. We found that most breast cancer cell lines had reduced or undetectable expression of NRG1. This included cell lines that had translocation breaks in the gene. Similarly, expression in...
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