Article
Bone marrow transplantation modulates tissue macrophage phenotype and enhances cardiac recovery after subsequent acute myocardial infarction.
Journal of molecular and cellular cardiology - 1 Jan 2016
Protti Andrea, Mongue-Din Heloise, Mylonas Katie J, Sirker Alexander, Sag Can Martin, Swim Megan M, Maier Lars, Sawyer Greta, Dong Xuebin, Botnar Rene, Salisbury Jon, Gray Gillian A, Shah Ajay M
Abstract excerpt
BACKGROUND: Bone marrow transplantation (BMT) is commonly used in experimental studies to investigate the contribution of BM-derived circulating cells to different disease processes. During studies investigating the cardiac response to acute myocardial infarction (MI) induced by permanent coronary ligation in mice that had previously undergone BMT, we found that BMT itself affects the remodelling response....
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