Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The cell of origin and the leukemia stem cell in acute myeloid leukemia

31 Aug 2019

Abstract excerpt

There is experimental and observational evidence that the cells of the leukemic clone in acute myeloid leukemia (AML) have different phenotypes even though they share the same somatic mutations. The organization of the malignant clone in AML has many similarities to normal hematopoiesis, with leukemia stem cells (LSCs) that sustain leukemia and give rise to more differentiated cells. LSCs, similar to normal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Hematopoietic Stem Cell Transplantation
Share to Sarcoma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31471945
DOI: 10.1002/gcc.22805

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The cell of origin and the leukemia stem cell in acute myeloid leukemiaPMID 31471945Read ↗

Leukemia stem cellsSemantic proximity Read ↗

Leukemia stem cells.Semantic proximity Read ↗

Acute myeloid leukemia stem cells: seek and destroySemantic proximity Read ↗

Leukemic Stem Cells and Hematological Malignancies.Semantic proximity Read ↗

Leukemic Stem Cells: From Leukemic Niche Biology to Treatment Opportunities.Semantic proximity Read ↗

The leukemic stem cell niche: current concepts and therapeutic opportunitiesSemantic proximity Read ↗

Concise Review: Preleukemic Stem Cells: Molecular Biology and Clinical Implications of the Precursors to Leukemia Stem CellsSemantic proximity Read ↗

Aberrant stem cell and developmental programs in pediatric leukemiaSemantic proximity Read ↗

A shadow in the treatment of acute leukemia: lineage switchSemantic proximity Read ↗

Concise Review: The Role of Hematopoietic Stem Cell Transplantation in the Treatment of Acute Myeloid LeukemiaSemantic proximity Read ↗

The molecular basis of leukemia.Semantic proximity Read ↗

Eradication of Leukemia Stem Cells as a New Goal of Therapy in LeukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.