Article
c-Myc and Her2 cooperate to drive a stem-like phenotype with poor prognosis in breast cancer.
Oncogene - 24 Jul 2014
Nair R, Roden D L, Teo W S, McFarland A, Junankar S, Ye S, Nguyen A, Yang J, Nikolic I, Hui M, Morey A, Shah J, Pfefferle A D, Usary J, Selinger C, Baker L A, Armstrong N, Cowley M J, Naylor M J, Ormandy C J, Lakhani S R, Herschkowitz J I, Perou C M, Kaplan W, O'Toole S A, Swarbrick A
Abstract excerpt
The HER2 (ERBB2) and MYC genes are commonly amplified in breast cancer, yet little is known about their molecular and clinical interaction. Using a novel chimeric mammary transgenic approach and in vitro models, we demonstrate markedly increased self-renewal and tumour-propagating capability of cells transformed with Her2 and c-Myc. Coexpression of both oncoproteins in cultured cells led to the activation of a...
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