Article
Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibition.
Molecular cancer therapeutics - 1 Feb 2007
Buck Elizabeth, Eyzaguirre Alexandra, Barr Sharon, Thompson Stuart, Sennello Regina, Young David, Iwata Kenneth K, Gibson Neil W, Cagnoni Pablo, Haley John D
Abstract excerpt
Overexpression and enhanced activation of the epidermal growth factor receptor (EGFR) is frequently observed in human carcinomas. Inhibitors of EGFR signaling have shown clinical utility; however, understanding response at the molecular level is important to define patient subsets most likely to benefit, as well as to support the rational design of drug combinations. Pancreatic and colorectal tumor cell lines...
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