Tigecycline resistance in clinical isolates of <i>Enterococcus faecium</i> is mediated by an upregulation of plasmid-encoded tetracycline determinants <i>tet</i> (L) and <i>tet</i> (M)

Abstract excerpt

OBJECTIVES: Tigecycline represents one of the last-line therapeutics to combat multidrug-resistant bacterial pathogens, including VRE and MRSA. The German National Reference Centre for Staphylococci and Enterococci has received 73 tigecycline-resistant Enterococcus faecium and Enterococcus faecalis isolates in recent years. The precise mechanism of how enterococci become resistant to tigecycline remains...

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