Article
Additional chromosomal abnormalities in core-binding factor acute myeloid leukemia.
Genetics and molecular research : GMR - 16 Dec 2015
Hsiao H H, Liu Y C, Wang H C, Tsai Y F, Wu C H, Cho S F, Hsu J F, Huang C T, Hsiao S Y, Lee C P, Chang C S, Lin S F, Liu T C
Abstract excerpt
Despite sharing a similar genetic abnormality, patients with core binding factor acute myeloid leukemia (CBF-AML), which is characterized by the presence of t(8;21) or inv(16)/t(16;16), show heterogeneous survival. Other molecular or cytogenetic factors are supposed to have an impact on the prognosis. We enrolled 24 CBF-AML patients to determine the impact of cytogenetic abnormality, and c-KIT, FLT3, NPM1, and...
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