Article
A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males.
Journal of psychiatry & neuroscience : JPN - 1 Apr 2016
Stacey David, Lourdusamy Anbarasu, Ruggeri Barbara, Maroteaux Matthieu, Jia Tianye, Cattrell Anna, Nymberg Charlotte, Banaschewski Tobias, Bhattacharyya Sohinee, Band Hamid, Barker Gareth, Bokde Arun, Buchel Christian, Carvalho Fabiana, Conrod Patricia, Desrivieres Sylvane, Easton Alanna, Fauth-Buehler Mira, Fernandez-Medarde Alberto, Flor Herta, Frouin Vincent, Gallinat Jurgen, Garavanh Hugh, Heinz Andreas, Ittermann Bernd, Lathrop Mark, Lawrence Claire, Loth Eva, Mann Karl, Martinot Jean-Luc, Nees Frauke, Paus Tomas, Pausova Zdenka, Rietschel Marcella, Rotter Andrea, Santos Eugenio, Smolka Michael, Sommer Wolfgang, Mameli Manuel, Spanagel Rainer, Girault Jean-Antoine, Mueller Christian, Schumann Gunter
Abstract excerpt
BACKGROUND: The mesolimbic dopamine system, composed primarily of dopaminergic neurons in the ventral tegmental area that project to striatal structures, is considered to be the key mediator of reinforcement-related mechanisms in the brain. Prompted by a genome-wide association meta-analysis implicating the Ras-specific guanine nucleotide-releasing factor 2 (RASGRF2) gene in the regulation of alcohol intake in...
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