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Article

A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer.

Cancer cell - 14 Dec 2015

von Eyss Björn, Jaenicke Laura A, Kortlever Roderik M, Royla Nadine, Wiese Katrin E, Letschert Sebastian, McDuffus Leigh-Anne, Sauer Markus, Rosenwald Andreas, Evan Gerard I, Kempa Stefan, Eilers Martin

Abstract excerpt

In several developmental lineages, an increase in MYC expression drives the transition from quiescent stem cells to transit-amplifying cells. We show that MYC activates a stereotypic transcriptional program of genes involved in cell growth in mammary epithelial cells. This change in gene expression indirectly inhibits the YAP/TAZ co-activators, which maintain the clonogenic potential of these cells. We identify a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26678338
DOI: 10.1016/j.ccell.2015.10.013

Genes

MYC
PLD6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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