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Article

Elimination of methylation marks at lysines 4 and 9 of histone 3 (H3K4 and H3K9) of spermatozoa alters offspring phenotype.

Reproduction, fertility, and development - 1 Apr 2017

Pérez-Cerezales Serafín, Ramos-Ibeas Priscila, Lopez-Cardona Angela, Pericuesta Eva, Fernandez-Gonzalez Raúl, Pintado Belen, Gutiérrez-Adán Alfonso

Abstract excerpt

The contribution of the contents of spermatozoa to the development of the embryo is currently being considered wider than was previously thought. Recent findings point to the participation of epigenetic marks present in the retained histones of mature spermatozoa on embryo and fetal development. Here we created a novel conditional transgenic mouse that expresses lysine (K) demethylase 1a (Kdm1a) during...

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Identifiers

PMID: 26678259
DOI: 10.1071/RD15349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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