Article
Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jan 2016
Eng Christina H, Wang Zuncai, Tkach Diane, Toral-Barza Lourdes, Ugwonali Savuth, Liu Shanming, Fitzgerald Stephanie L, George Elizabeth, Frias Elizabeth, Cochran Nadire, De Jesus Rowena, McAllister Gregory, Hoffman Gregory R, Bray Kevin, Lemon LuAnna, Lucas Judy, Fantin Valeria R, Abraham Robert T, Murphy Leon O, Nyfeler Beat
Abstract excerpt
Macroautophagy is a key stress-response pathway that can suppress or promote tumorigenesis depending on the cellular context. Notably, Kirsten rat sarcoma (KRAS)-driven tumors have been reported to rely on macroautophagy for growth and survival, suggesting a potential therapeutic approach of using autophagy inhibitors based on genetic stratification. In this study, we evaluated whether KRAS mutation status can...
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