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Article

Gold Nanoparticles Inhibit Macropinocytosis by Decreasing KRAS Activation.

ACS nano - 23 May 2023

Elechalawar Chandra Kumar, Rao Geeta, Gulla Suresh Kumar, Patel Maulin Mukeshchandra, Frickenstein Alex, Means Nicolas, Roy Ram Vinod, Tsiokas Leonidas, Asfa Sima, Panja Prasanta, Rao Chinthalapally, Wilhelm Stefan, Bhattacharya Resham, Mukherjee Priyabrata

Abstract excerpt

The RAS-transformed cells utilize macropinocytosis to acquire amino acids to support their uncontrolled growth. However, targeting RAS to inhibit macropinocytosis remains a challenge. Here, we report that gold nanoparticles (GNP) inhibit macropinocytosis by decreasing KRAS activation. Using surface-modified and unmodified GNP, we showed that unmodified GNP specifically sequestered both wild-type and mutant KRAS...

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Identifiers

PMID: 37129853
DOI: 10.1021/acsnano.3c00920
PMCID: PMC10718652

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