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Article

CX-4945 (Silmitasertib) Induces Cell Death by Impairing Lysosomal Utilization in KRAS Mutant Cholangiocarcinoma Cell Lines.

Anticancer research - 1 May 2024

Lee DA Sol, Han Min Woo, Kang Yonghyun, Kim Chorong, Lee Seonmin, Kim Kyu-Pyo, Yoo Changhoon

Abstract excerpt

BACKGROUND/AIM: Macropinocytosis is a non-selective form of endocytosis that facilitates the uptake of extracellular substances, such as nutrients and macromolecules, into the cells. In KRAS-driven cancers, including pancreatic ductal adenocarcinoma, macropinocytosis and subsequent lysosomal utilization are known to be enhanced to overcome metabolic stress. In this study, we investigated the role of Casein Kinase...

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PMID: 38677763
DOI: 10.21873/anticanres.16996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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CX-4945 (Silmitasertib) Induces Cell Death by Impairing Lysosomal Utilization in KRAS Mutant Cholangiocarcinoma Cell Lines.PMID 38677763Read ↗

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