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Article

Is there a causal role for homocysteine concentration in blood pressure? A Mendelian randomization study.

The American journal of clinical nutrition - 1 Jan 2016

Borges Maria C, Hartwig Fernando P, Oliveira Isabel O, Horta Bernardo L

Abstract excerpt

BACKGROUND: An understanding of whether homocysteine is a cause or a marker of increased blood pressure is relevant because blood homocysteine can be effectively lowered by safe and inexpensive interventions (e.g., vitamin B-6, B-9, and B-12 supplementation). OBJECTIVE: The aim was to assess the causal influence of homocysteine on systolic and diastolic blood pressure (SBP and DBP, respectively) in adults with...

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Source

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Identifiers

PMID: 26675774
DOI: 10.3945/ajcn.115.116038
PMCID: PMC4691668

Genes

DBP
MTHFR

Variants

rs1801133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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