Article
Elucidation of CYP2D6 genetic diversity in a unique African population: implications for the future application of pharmacogenetics in the Xhosa population.
Annals of human genetics - 1 Jul 2010
Wright Galen E B, Niehaus Dana J H, Drögemöller Britt I, Koen Liezl, Gaedigk Andrea, Warnich Louise
Abstract excerpt
Genetic variation of the CYP2D6 gene has been associated with altered drug metabolism; however, limited studies have investigated CYP2D6 sequence diversity in African populations. We devised a CYP2D6 genotyping strategy to analyse the South African Xhosa population and genotype a Xhosa schizophrenia cohort, as CYP2D6 metabolises many antipsychotics and antidepressants. The entire CYP2D6 gene locus was sequenced...
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