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Article

DNA recognition for virus assembly through multiple sequence-independent interactions with a helix-turn-helix motif.

Nucleic acids research - 29 Jan 2016

Greive Sandra J, Fung Herman K H, Chechik Maria, Jenkins Huw T, Weitzel Stephen E, Aguiar Pedro M, Brentnall Andrew S, Glousieau Matthieu, Gladyshev Grigory V, Potts Jennifer R, Antson Alfred A

Abstract excerpt

The helix-turn-helix (HTH) motif features frequently in protein DNA-binding assemblies. Viral pac site-targeting small terminase proteins possess an unusual architecture in which the HTH motifs are displayed in a ring, distinct from the classical HTH dimer. Here we investigate how such a circular array of HTH motifs enables specific recognition of the viral genome for initiation of DNA packaging during virus...

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Identifiers

PMID: 26673721
DOI: 10.1093/nar/gkv1467
PMCID: PMC4737164

Genes

SPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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