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Article

Human RNase L tunes gene expression by selectively destabilizing the microRNA-regulated transcriptome.

Proceedings of the National Academy of Sciences of the United States of America - 29 Dec 2015

Rath Sneha, Donovan Jesse, Whitney Gena, Chitrakar Alisha, Wang Wei, Korennykh Alexei

Abstract excerpt

Double-stranded RNA (dsRNA) activates the innate immune system of mammalian cells and triggers intracellular RNA decay by the pseudokinase and endoribonuclease RNase L. RNase L protects from pathogens and regulates cell growth and differentiation by destabilizing largely unknown mammalian RNA targets. We developed an approach for transcriptome-wide profiling of RNase L activity in human cells and identified...

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PMID: 26668391
DOI: 10.1073/pnas.1513034112
PMCID: PMC4702973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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