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Article

Activation of the antiviral factor RNase L triggers translation of non-coding mRNA sequences

4 Feb 2021

Abstract excerpt

Ribonuclease L (RNase L) is activated as part of the innate immune response and plays an important role in the clearance of viral infections. When activated, it endonucleolytically cleaves both viral and host RNAs, leading to a global reduction in protein synthesis. However, it remains unknown how widespread RNA decay, and consequent changes in the translatome, promote the elimination of viruses. To study how...

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PMID: 33556964
DOI: 10.1093/nar/gkab036

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