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Article

Regulation of human RNase-L by the miR-29 family reveals a novel oncogenic role in chronic myelogenous leukemia.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Jan 2013

Lee Teresa Y, Ezelle Heather J, Venkataraman Thiagarajan, Lapidus Rena G, Scheibner Kara A, Hassel Bret A

Abstract excerpt

The endoribonuclease RNase-L is the terminal component of an interferon-regulated RNA decay pathway known as the 2'-5'-oligoadenylate (2-5A) system, whose established functions include antimicrobial and tumor suppressive activities. RNase-L activity requires binding of the small molecule 2-5A, leading to RNase-L dimerization and cleavage of single-stranded RNA. RNase-L expression is controlled...

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Identifiers

PMID: 23113544
DOI: 10.1089/jir.2012.0062
PMCID: PMC3539258

Genes

RNASEL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of human RNase-L by the miR-29 family reveals a novel oncogenic role in chronic myelogenous leukemia.PMID 23113544Read ↗

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