Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Unusual Role of Ribonuclease L in Innate Immunity

1 Nov 2024

Abstract excerpt

Ribonuclease L is an endonuclease that is activated as part of the dsRNA-driven innate immune response. Active RNase L cleaves pathogenic RNAs as a way to eliminate infections. However, there are additional and unexpected ways that RNase L causes changes in the host that promote an immune response and contribute to its role in host defense. Central to these unconventional mechanisms is the observation that RNase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to interferon and immune responses
Share to RNA regulation and disease
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39727035
DOI: 10.1002/wrna.1878

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Unusual Role of Ribonuclease L in Innate ImmunityPMID 39727035Read ↗

RNase L Amplifies Interferon Signaling by Inducing Protein Kinase R-Mediated Antiviral Stress GranulesSemantic proximity Read ↗

Activation of the antiviral factor RNase L triggers translation of non-coding mRNA sequencesSemantic proximity Read ↗

Activation of the antiviral factor RNase L triggers translation of non-coding mRNA sequencesSemantic proximity Read ↗

RNase-L Control of Cellular mRNAs: Roles in Biologic Functions and Mechanisms of Substrate TargetingSemantic proximity Read ↗

RNase L Activates the NLRP3 Inflammasome during Viral InfectionsSemantic proximity Read ↗

RNase L releases a small RNA from HCV RNA that refolds into a potent PAMPSemantic proximity Read ↗

A central role for RNA in the induction and biological activities of type 1 interferonsSemantic proximity Read ↗

Regnase‐1–related endoribonucleases in health and immunological diseasesSemantic proximity Read ↗

Discrimination of cytosolic self and non-self RNA by RIG-I-like receptorsSemantic proximity Read ↗

Human RNase L tunes gene expression by selectively destabilizing the microRNA-regulated transcriptome.Semantic proximity Read ↗

RNA is taking its Toll: Impact of RNA‐specific Toll‐like receptors on health and diseaseSemantic proximity Read ↗

Ro60—Roles in RNA Processing, Inflammation, and Rheumatic Autoimmune DiseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.