Article
Association of APOL1 Genotype with Renal Histology among Black HIV-Positive Patients Undergoing Kidney Biopsy.
Clinical journal of the American Society of Nephrology : CJASN - 5 Feb 2016
Atta Mohamed G, Estrella Michelle M, Skorecki Karl L, Kopp Jeffrey B, Winkler Cheryl A, Wasser Walter G, Shemer Revital, Racusen Lorraine C, Kuperman Michael, Foy Matthew C, Lucas Gregory M, Fine Derek M
Abstract excerpt
BACKGROUND AND OBJECTIVES: Prior studies have shown that the APOL1 risk alleles are associated with a greater risk of HIV-associated nephropathy and FSGS among blacks who are HIV positive. We sought to determine whether the APOL1 high-risk genotype incrementally improved the prediction of these underlying lesions beyond conventional clinical factors. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In a...
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