The TPx Protein of Cysticercus cellulosae Promotes an IL-10-Producing Regulatory B Cell Phenotype in Human B Lymphoblastoid Cells via the cAMP/CREB Pathway.

doi:10.3390/cells15161429

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The TPx Protein of Cysticercus cellulosae Promotes an IL-10-Producing Regulatory B Cell Phenotype in Human B Lymphoblastoid Cells via the cAMP/CREB Pathway.

Cells - 8 Aug 2026

Cai Haojun, Li Xue, Xiong Haiting, Mu Qianqian, Zhou Biying

Abstract excerpt

Thioredoxin peroxidase (TPx) derived from Taenia solium cysticerci (Cysticercus cellulosae) mediates immune evasion by disrupting T cell subset homeostasis. However, its effect on regulatory B cells (Bregs) and the underlying mechanism remain unknown. We stimulated GM12878 B cells with TPx and assessed Breg differentiation by flow cytometry, ELISA, and RT-qPCR. We evaluated the function of TPx-pretreated B cells...

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PMID: 42645157
DOI: 10.3390/cells15161429
PMCID: PMC13511132

Genes

CD4
CD19

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.