Article
Polymorphisms of the artemisinin resistant marker (K13) in Plasmodium falciparum parasite populations of Grande Comore Island 10 years after artemisinin combination therapy.
Parasites & vectors - 15 Dec 2015
Huang Bo, Deng Changsheng, Yang Tao, Xue Linlu, Wang Qi, Huang Shiguang, Su Xin-zhuan, Liu Yajun, Zheng Shaoqin, Guan Yezhi, Xu Qin, Zhou Jiuyao, Yuan Jie, Bacar Afane, Abdallah Kamal Said, Attoumane Rachad, Mliva Ahamada M S A, Zhong Yanchun, Lu Fangli, Song Jianping
Abstract excerpt
BACKGROUND: Plasmodium falciparum malaria is a significant public health problem in Comoros, and artemisinin combination therapy (ACT) remains the first choice for treating acute uncomplicated P. falciparum. The emergence and spread of artemisinin-resistant P. falciparum in Southeast Asia, associated with mutations in K13-propeller gene, poses a potential threat to ACT efficacy. Detection of mutations in the P....
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