Article
SNEV(Prp19/PSO4) deficiency increases PUVA-induced senescence in mouse skin.
Experimental dermatology - 1 Mar 2016
Monteforte Rossella, Beilhack Georg F, Grausenburger Reinhard, Mayerhofer Benjamin, Bittner Reginald, Grillari-Voglauer Regina, Sibilia Maria, Dellago Hanna, Tschachler Erwin, Gruber Florian, Grillari Johannes
Abstract excerpt
Senescent cells accumulate during ageing in various tissues and contribute to organismal ageing. However, factors that are involved in the induction of senescence in vivo are still not well understood. SNEV(P) (rp19/) (PSO) (4) is a multifaceted protein, known to be involved in DNA damage repair and senescence, albeit only in vitro. In this study, we used heterozygous SNEV(+/-) mice (SNEV-knockout results in...
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