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Article

Comprehensive multiplatform biomarker analysis of 350 hepatocellular carcinomas identifies potential novel therapeutic options.

Journal of surgical oncology - 1 Jan 2016

Ang Celina, Miura John T, Gamblin T Clark, He Ruth, Xiu Joanne, Millis Sherri Z, Gatalica Zoran, Reddy Sandeep K, Yee Nelson S, Abou-Alfa Ghassan K

Abstract excerpt

BACKGROUND AND OBJECTIVES: Effective therapies for hepatocellular carcinoma (HCC) are limited. Molecular profiling of HCC was performed to identify novel therapeutic targets. METHODS: 350 HCC samples were evaluated using a multiplatform profiling service (Caris Life Sciences, Phoenix, AZ), including gene sequencing, amplification, and protein expression. RESULTS: EGFR, TOPO1, PD-1, TOP2A, SPARC, and c-Met were...

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Source

Identifiers

PMID: 26661118
DOI: 10.1002/jso.24086

Genes

CTNNB1
BRCA2
SPARC
EGFR
MGMT
PTEN
RRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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