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Article

GATA-2 regulates granulocyte-macrophage progenitor cell function.

Blood - 15 Dec 2008

Rodrigues Neil P, Boyd Ashleigh S, Fugazza Cristina, May Gillian E, Guo Yanping, Tipping Alex J, Scadden David T, Vyas Paresh, Enver Tariq

Abstract excerpt

The zinc finger transcription factor GATA-2 has been implicated in the regulation of hematopoietic stem cells. Herein, we explored the role of GATA-2 as a candidate regulator of the hematopoietic progenitor cell compartment. We showed that bone marrow from GATA-2 heterozygote (GATA-2(+/-)) mice displayed attenuated granulocyte-macrophage progenitor function in colony-forming cell (CFC) and serial replating CFC...

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Identifiers

PMID: 18840712
DOI: 10.1182/blood-2008-01-136564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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