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Article

Multilocus Inherited Neoplasia Alleles Syndrome: A Case Series and Review.

JAMA oncology - 1 Mar 2016

Whitworth James, Skytte Anne-Bine, Sunde Lone, Lim Derek H, Arends Mark J, Happerfield Lisa, Frayling Ian M, van Minkelen Rick, Woodward Emma R, Tischkowitz Marc D, Maher Eamonn R

Abstract excerpt

Mendelian causes of inherited cancer susceptibility are mostly rare and characterized by variable expression and incomplete penetrance. Phenotypic variability may result from a range of causes including locus heterogeneity, allelic heterogeneity, genetic and environmental modifier effects, or chance. Another potential cause is the presence of 2 or more inherited cancer predisposition alleles in the same...

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PMID: 26659639
DOI: 10.1001/jamaoncol.2015.4771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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