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Article

Cancer genomics and inherited risk.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Mar 2014

Stadler Zsofia K, Schrader Kasmintan A, Vijai Joseph, Robson Mark E, Offit Kenneth

Abstract excerpt

Next-generation sequencing (NGS) has enabled whole-exome and whole-genome sequencing of tumors for causative mutations, allowing for more accurate targeting of therapies. In the process of sequencing the tumor, comparisons to the germline genome may identify variants associated with susceptibility to cancer as well as other hereditary diseases. Already, the combination of massively parallel sequencing and...

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Identifiers

PMID: 24449244
DOI: 10.1200/JCO.2013.49.7271
PMCID: PMC5795694

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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